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Rapid Parallel Synthesis of Dipeptide Diphenyl Phosphonate Esters as Inhibitors of Dipeptidyl Peptidases

✍ Scribed by Senten, Kristel; Daniëls, Liesbeth; Van der Veken, Pieter; De Meester, Ingrid; Lambeir, Anne-Marie; Scharpé, Simon; Haemers, Achiel; Augustyns, Koen


Book ID
120495861
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
121 KB
Volume
5
Category
Article
ISSN
1520-4766

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Polymer-assisted solution-phase parallel
✍ Kristel Senten; Pieter Van der Veken; Gunther Bal; Achiel Haemers; Koen Augustyn 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 91 KB

This letter describes the parallel synthesis of dipeptide p-nitroanilides (1) and dipeptide diphenyl phosphonates (2), compounds that can be used as substrates and irreversible inhibitors for the rapid profiling of dipeptidyl peptidases. A polymer-assisted solution-phase synthesis was used for a rap