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Polymer-assisted solution-phase parallel synthesis of dipeptide p-nitroanilides and dipeptide diphenyl phosphonates

✍ Scribed by Kristel Senten; Pieter Van der Veken; Gunther Bal; Achiel Haemers; Koen Augustyns

Book ID: 104231999
Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 91 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01954-2

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✦ Synopsis

This letter describes the parallel synthesis of dipeptide p-nitroanilides (1) and dipeptide diphenyl phosphonates (2), compounds that can be used as substrates and irreversible inhibitors for the rapid profiling of dipeptidyl peptidases. A polymer-assisted solution-phase synthesis was used for a rapid and clean coupling between easily available building blocks.

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