Rapid one-step preparation of 123I, 125I and 131I-Hippuran of pharmaceutical quality
โ Scribed by G. Westera; H.J.M. van Gijlswijk; P.J. van der Jagt; J.F.W. Tertoolen
- Publisher
- Elsevier Science
- Year
- 1978
- Weight
- 194 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0020-708X
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๐ SIMILAR VOLUMES
## Abstract (__S__)โ(โ)โ__N__โ[(1โethylโ2โpyrrolidinyl)methyl]โ5โ[^123^I]iodoโ2,3โdimethoxybenzamide (TDP 517) (proposed generic name, [^123^I]epidepride) is the iodineโ123 substituted analogue of isoremoxipride (FLB 457), both of which are very potent dopamine Dโ2 antagonists (epidepride K~D~ 0.02
## Abstract In order to simplify preparation of [^123^I]PE2I, iodogen and hydrogen peroxide were examined as oxidants for the preparation of radioiodinated PE2I, e.g. (__E__)โ__N__โ(3โiodopropโ2โenyl)โ2__ฮฒ__โcarbomethoxyโ3__ฮฒ__โ(4โฒโtolyl) nortropane). Among the oxidizing compounds assayed, iodogen