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Rapid Microwave Promoted Sonogashira Coupling Reactions on Solid Phase

✍ Scribed by Erdélyi, Máté; Gogoll, Adolf

Book ID
111904346
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
59 KB
Volume
68
Category
Article
ISSN
0022-3263

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A microwave-enhanced, solventless Sonogashira coupling reaction has been developed. Terminal alkynes couple with aryl or alkenyl iodide on palladium-doped alumina in the presence of triphenylphosphine and cuprous iodide to provide high yields of products.

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