Rapid isolation of translocation breakpoints in chronic myeloid and acute promyelocytic leukaemia
โ Scribed by Paul A. Bartley; Michael H. Martin-Harris; Bradley J. Budgen; David M. Ross; Alexander A. Morley
- Book ID
- 108676669
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 150 KB
- Volume
- 149
- Category
- Article
- ISSN
- 0007-1048
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Fourteen patients with poor-risk acute myelogenous leukaemia (AML) and five patients with accelerated phase/blast crisis chronic myeloid leukaemia (CML) were treated with 3 days of oral idarubicin (25 mg/m2/ day). No complete remissions or return to chronic phase CML were observed. A fall in the per
A t(3;5)(q25. I ;q34) reciprocal translocation identifies a subset of cases of myelodysplastic syndrome o r acute myeloid leukemia (AML) that are characterized by increased numbers of megakaryocytes and severe trilineage dysplasia. As a first step in characterizing the t(3;5) breakpoints, we asked w