## Abstract Dendritic cells hold promise as adjuvant for immunotherapy for cancer and infectious diseases. We demonstrate that a significant number of cryopreserved peripheral blood CD34^+^ cells from HIVโinfected subjects can be transduced with a replicationโincompetent lentiviral vector expressin
Rapid generation of dendritic cell specific transgenic mice by lentiviral vectors
โ Scribed by Jinyu Zhang; Liyun Zou; Qin Liu; Jingyi Li; Jingran Zhou; Yong Wang; Na Li; Ting Liu; Hong Wei; Min Wu; Ying Wan; Yuzhang Wu
- Publisher
- Springer Netherlands
- Year
- 2009
- Tongue
- English
- Weight
- 467 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0962-8819
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Background Genetically engineered dendritic cells (DC) presenting specific antigens to T cells may be of great interest for immunotherapy. For this reason, the production of transgene-expressing DC derived from CD34+ cells transduced either shortly after ex vivo purification or during their differen
## Abstract Transgenic and geneโtargeted mutant mice provide powerful tools for analysis of the cellular processes involved in early development and in the pathogenesis of many diseases. Here we describe a transgene integration strategy mediated by siteโspecific recombination that allows establishm
Previous studies on cell cycle regulation in the ocular lens using transgenic mice have shown that inactivation of the retinoblastoma tumor suppressor protein (pRb) can cause postmitotic lens fiber cells to enter the cell cycle. However, when the p53 gene and protein are intact, inactivation of pRb