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Rapid evolution of HIV-1 to functional CD8+ T-cell rResponses in humanized BLT mice

✍ Scribed by TE Dudek, DC No, E Seung, V Vrbanac, L Fadda, KF Bryant, M Altfeld…


Book ID
120691315
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
75 KB
Volume
9
Category
Article
ISSN
1742-4690

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## Abstract The hallmark of chronic viral infections is a progressive exhaustion of antigen‐specific CD8^+^ T cells that leads to persisting viral replication. It is generally believed that exhaustion is a consequence of the accumulation of multiple inhibitory receptors on CD8^+^ T cells that makes