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Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection

✍ Scribed by Marina Cella; Rachel Presti; William Vermi; Kerry Lavender; Emma Turnbull; Christina Ochsenbauer-Jambor; John C. Kappes; Guido Ferrari; Lisa Kessels; Ian Williams; Andrew J. McMichael; Barton F. Haynes; Persephone Borrow; Marco Colonna

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 350 KB
Volume: 40
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.200940234

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✦ Synopsis

Abstract

The hallmark of chronic viral infections is a progressive exhaustion of antigen‐specific CD8^+^ T cells that leads to persisting viral replication. It is generally believed that exhaustion is a consequence of the accumulation of multiple inhibitory receptors on CD8^+^ T cells that makes them dysfunctional. Here, we show that during human chronic HIV‐1 infection, a CD8^+^ T‐cell positive costimulatory pathway mediated by DNAX‐activating molecule‐1 is also disrupted. Thus, DNAX‐activating molecule‐1 downregulation on CD8^+^ T cells aggravates the impairment of CTL effector function in chronic HIV‐1 infection.

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