## Abstract The hallmark of chronic viral infections is a progressive exhaustion of antigenβspecific CD8^+^ T cells that leads to persisting viral replication. It is generally believed that exhaustion is a consequence of the accumulation of multiple inhibitory receptors on CD8^+^ T cells that makes
CD8+ cytolytic T lymphocytes become infected in vitro in the process of killing HIV-1-infected target cells
β Scribed by Andrea De Maria; Sandra Colombini; Steven M. Schnittman; Lorenzo Moretta
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 677 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
For some membrane-associated antigens, the number of molecules expressed per cell carries information about the cell's differentiation and activation state. Quantitating antigen expression by flow cytometry has immediate application in monitoring CD38 expression on CD8 Ψ T cells in human immunodefic
## Abstract Excessive immune activation is a hallmark of chronic uncontrolled HIV infection. During the past years, growing evidence suggests that immune inhibitory signals also play an important role in progressive disease. However, the relationship between positive and negative immune signals on