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Rapid differentiation of five common α-thalassemia genotypes by polymerase chain reaction

✍ Scribed by Delia C Tang; Suthat Fucharoen; Ivan Ding; Griffin P Rodgers

Book ID
114486419
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
149 KB
Volume
137
Category
Article
ISSN
1532-6543

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Asian couples at risk for a fetus with homozygous alpha-thalassemia (hydrops fetalis) are often identified by their low erythrocyte mean corpuscular volume (MCV) and normal hemoglobin electrophoresis when little time remains to test their genotypes by restriction enzyme analysis. DNA analysis is per