Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), may be related to reduced biosynthesis of nitric oxide in diseases associated with accelerated atherosclerosis. The closely related compound symmetric dimethylarginine (SDMA) does not inhibit NOS, but may com
Rapid Determination of Underivatized Arginine, Ornithine, Citrulline and Symmetric/Asymmetric Dimethylarginine in Human Plasma by LC–MS
✍ Scribed by Hong-Yun Wang; Pei Hu; Ji Jiang
- Book ID
- 111791960
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 558 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0009-5893
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## Abstract Arginine (ARG) is a substrate for endogenous nitric oxide (NO) production whereas its metabolite, asymmetric dimethylarginine (ADMA), acts as an inhibitor. Sufficient NO production is essential for cardiovascular key functions, thus elevated concentration levels of ADMA are related to a