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Rapid determination of apixaban concentration in human plasma by liquid chromatography/tandem mass spectrometry: Application to pharmacokinetic study

โœ Scribed by Delavenne, Xavier; Mismetti, Patrick; Basset, Thierry

Book ID
119963226
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
430 KB
Volume
78-79
Category
Article
ISSN
0731-7085

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## Abstract A rapid and sensitive LC/MS/MS assay was developed and validated for the determination of clopidogrel in human plasma. Clopidogrel was extracted by single liquidโ€“liquid extraction with pentane, and chromatographic separations were achieved on a C~18~ column. The method was validated to