Selected aneuploidies can be rapidly diagnosed by the analysis of fluorescent polymerase chain reaction (PCR) products of chromosomespecific and highly polymorphic small tandem repeats (STRs). The quantitative STR patterns obtained from samples of normal individuals are markedly different from those
Rapid detection of common autosomal aneuploidies by quantitative fluorescent PCR on uncultured amniocytes
✍ Scribed by Rahil, Haissam; Solassol, Jérome; Philippe, Christophe; Lefort, Geneviève; Jonveaux, Philippe
- Book ID
- 110025254
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 85 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1018-4813
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Quantitative fluorescent polymerase chain reaction (QF-PCR) assays and small tandem repeat (STR) markers have been successfully employed for the rapid detection of major numerical aneuploidies affecting human autosomes. So far, the analysis of chromosomes X and Y disorders has been hampered by the r
Several studies have been performed to assess the diagnostic value of using small tandem repeat (STR) markers and quantitative fluorescent polymerase chain reaction (QF-PCR) assays for the rapid detection of aneuploidies involving chromosomes