High-Throughput Assays for Botulinum Neu
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James J. Schmidt; Robert G. Stafford; Charles B. Millard
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Article
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2001
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Elsevier Science
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English
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Botulinum neurotoxins (BoNT) are zinc metalloproteases that cleave and inactivate cellular proteins essential for neurotransmitter release. Because the paralytic effect of BoNT is a consequence of its enzymatic activity, selective inhibitors may be useful as drugs or as tools for further research. T