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Fluorigenic Substrates for the Protease Activities of Botulinum Neurotoxins, Serotypes A, B, and F

✍ Scribed by Schmidt, J. J.; Stafford, R. G.

Book ID
126022733
Publisher
American Society for Microbiology
Year
2003
Tongue
English
Weight
232 KB
Volume
69
Category
Article
ISSN
0099-2240

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Botulinum neurotoxins (BoNT) are zinc metalloproteases that cleave and inactivate cellular proteins essential for neurotransmitter release. Because the paralytic effect of BoNT is a consequence of its enzymatic activity, selective inhibitors may be useful as drugs or as tools for further research. T