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Rapid and selective detritylation of primary alcohols using formic acid

โœ Scribed by Michel Bessodes; Dimitri Komiotis; Kostas Antonakis

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
111 KB
Volume
27
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A facile and chemoselective method of detritylation is described.

Several polyfunctionalized examples were tested to emphasize the selectivity of the system over different protecting groups.

๐Ÿ“œ SIMILAR VOLUMES

Facile selective detritylation of 5โ€ฒ-pri
Facile selective detritylation of 5โ€ฒ-primary alcohols of pyrimidine nucleosides using tetra-n-butylammonium peroxydisulfate
โœ Seung Gak Yang; Dong Hoon Lee; Yong Hae Kim ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 146 KB ๐Ÿ‘ 1 views

Tetra-n-butylammonium peroxydisulfate has been found to be a good deprotecting reagent for removal of the trityl group: Treatment of 5ะˆ-O-dimethoxytrityl uridine or thymidine with tetra-n-butylammonium peroxydisulfate gave the corresponding dedimethoxytritylated nucleosides in excellent yields under