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Rapid acetylation of alcohols at the microgram level using a celite-acetyl methanesulfonate column

โœ Scribed by Daniel P. Schwartz

Book ID
102628162
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
286 KB
Volume
71
Category
Article
ISSN
0003-2697

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โœฆ Synopsis

A simple procedure is described in which micro-and submicrogram amounts of primary, secondary, and several tertiary alcohols can be acetylated. The alcohols, dissolved in a nonpolar solvent, contact a column of Celite charged with the mixed anhydride, acetyl methanesulfonate, contained in a melting-point capillary. The resulting acetate is then eluted for analysis. The entire procedure can be executed in less than a minute. Micromole amounts of alcohols can be acetylated in good yield using larger columns.

๐Ÿ“œ SIMILAR VOLUMES

Use of a celite-potassium tert.-butoxide
Use of a celite-potassium tert.-butoxide column for rapid saponification of microgram amounts of glycerides at room temperature
โœ Daniel P. Schwartz ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 486 KB

In a simple, two-phase procedure, a capillary tube containing a bed of potassium tert.-butoxide supported on Celite 545 is used to saponify microgram amounts of glycerides applied toit in n-hexane. The reaction is carried out at room temperature and is complete wit&h 3 min. The fatty acids are recov