Rapid access to morphinones: removal of 4,5-ether bridge with Pd-catalyzed triflate reduction

✍ Scribed by Christopher D. Hupp; John L. Neumeyer

• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 370 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.02.146

✦ Synopsis

A new synthetic method for the removal of the 4,5-bridged ether moiety of several opioids has been developed. This process offers a faster, simpler synthetic route to obtain the morphinone scaffold in high yields without the need for protection of the ketone moiety.