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ChemInform Abstract: Rapid Access to Morphinones: Removal of 4,5-Ether Bridge with Pd-Catalyzed Triflate Reduction.

โœ Scribed by Christopher D. Hupp; John L. Neumeyer

Publisher
John Wiley and Sons
Year
2010
Weight
26 KB
Volume
41
Category
Article
ISSN
0931-7597

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Rapid access to morphinones: removal of
Rapid access to morphinones: removal of 4,5-ether bridge with Pd-catalyzed triflate reduction
โœ Christopher D. Hupp; John L. Neumeyer ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 370 KB

A new synthetic method for the removal of the 4,5-bridged ether moiety of several opioids has been developed. This process offers a faster, simpler synthetic route to obtain the morphinone scaffold in high yields without the need for protection of the ketone moiety.