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Rapid access to cis 3-substituted prolines

✍ Scribed by Nadia Pellegrini; Martine Schmitt; Jean-Jacques Bourguignon

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 100 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)01476-x

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✦ Synopsis

The O-triflate of 2-cyano-3-oxopyrrolidine was obtained and used in a palladium coupling reaction. The resulting D 2 -pyrrolidine derivatives allowed diastereocontrol at C2 and C3 after catalytic hydrogenation and led to chiral 3-substituted prolines as conformationally constrained amino acids.

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