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A rapid stereoselective access to highly substituted piperidines

✍ Scribed by Sophie Rougnon Glasson; Jean-Louis Canet; Yves Troin

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 85 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01730-5

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✦ Synopsis

An intramolecular Mannich reaction, involving various achiral aldehydes together with an a-chiral amine is employed as the key step for a stereocontrolled synthesis of highly substituted piperidine systems. Accordingly, 12 new piperidines bearing four asymmetric centers were prepared in six steps from commercial ketones.

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