This study represents the first systematic attempt to rank methemoglobin-forming agents. It is a quantitative potency ranking study utilizing linear regression analysis of dose-response data for comparative purposes. Six agents that are direct-acting and eight that require bioactivation were tested
Ranking of carcinogenic potency using a relative potency approach
โ Scribed by Larry R. Glass; Clay E. Easterly; Troyce D. Jones; Philip J. Walsh
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 841 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0090-4341
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Current approaches to skin sensitisation risk assessment are dependent upon the availability of information regarding two fundamental parameters. Firstly, data relating to the relative skin sensitising potency of the chemical, and secondly, information regarding likely conditions of human exposure.
For inference regarding relative potency in dilution assays with possible latent effects, a robust procedure is proposed. Monte Carlo studies show that this procedure compares favourably with h o r n procedures. The theory is illustrated by an application to the tolerances of c a b for tinctures of
Molecular orbital calculations were carried out on a series of model ketonic protease inhibitors. A comparison of the LUMO energy of the ketones in a variety of model heterocyclic ketone protease inhibitors shows a correlation with the electrophilicity of the carbonyl, and the ~ experimental data. I