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Randomized Play-the-Winner Clinical Trials: Review and Recommendations

โœ Scribed by William F. Rosenberger


Book ID
114187674
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
143 KB
Volume
20
Category
Article
ISSN
0197-2456

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๐Ÿ“œ SIMILAR VOLUMES


PLAY THE WINNER FOR PHASE II/III CLINICA
โœ Q. YAO; L. J. WEI ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 642 KB

In comparing two treatments under a typical sequential clinical trial setting, a 50-50 randomization design generates reliable data for making efficient inferences about the treatment difference for the benefit of patients in the general population. However, if the treatment difference is large and

A comparison of the randomized play-the-
โœ D. S. Coad; William F. Rosenberger ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 91 KB ๐Ÿ‘ 3 views

We consider a clinical trial model comparing an experimental treatment with a control treatment when the responses are binary. For fixed significance level and power, we compare the expected number of treatment failures for two designsthe randomized play-the-winner rule and the triangular test. The