In comparing two treatments under a typical sequential clinical trial setting, a 50-50 randomization design generates reliable data for making efficient inferences about the treatment difference for the benefit of patients in the general population. However, if the treatment difference is large and
Variance in randomized play-the-winner clinical trials
โ Scribed by Peter C. Matthews; William F. Rosenberger
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 379 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0167-7152
No coin nor oath required. For personal study only.
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We consider a clinical trial model comparing an experimental treatment with a control treatment when the responses are binary. For fixed significance level and power, we compare the expected number of treatment failures for two designsthe randomized play-the-winner rule and the triangular test. The
Between-community variance or community-by-time variance is one of the key factors driving the cost of conducting group randomized trials, which are often very expensive. We investigated empirically whether between-community variance could be reduced by controlling individual-and/or community-level