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Random mtDNA deletions and functional consequence in aged human skeletal muscle

✍ Scribed by Béatrice Chabi; Bénédicte Mousson de Camaret; Arnaud Chevrollier; Stéphane Boisgard; Georges Stepien


Book ID
116290580
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
376 KB
Volume
332
Category
Article
ISSN
0006-291X

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Large-scale deletions of mitochondrial DNA (mtDNA) have been associated with a subgroup of mitochondrial encephalomyopathies, usually characterized by progressive external ophthalmoplegia (PEO) and mitochondrial proliferation in muscle fibers. We and others have shown that muscle from patients with