Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing
โ Scribed by J.M. Cooper; V.M. Mann; A.H.V. Schapira
- Book ID
- 118931563
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 582 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0022-510X
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The abundance of mitochondrial DNA (mtDNA) deletions has been shown to increase with age in a number of species and may contribute to the aging process. Estimating the total mtDNA deletion load of an individual is essential in evaluating the potential physiological impact. In this study, we compared
## Communicated by Henrik Dahl Seven mtDNA mutations (five base substitutions and two deletions) were studied in skeletal muscle samples of 18 human subjects aged 1 hr to 90 years. Quantitative PCR procedures were applied to determine the incidence (frequency of occurrence) and abundance (percentag