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RALBP1/RLIP76 Depletion in Mice Suppresses Tumor Growth by Inhibiting Tumor Neovascularization

✍ Scribed by Lee, S.; Wurtzel, J. G. T.; Singhal, S. S.; Awasthi, S.; Goldfinger, L. E.

Book ID: 115537445
Publisher: American Association for Cancer Research
Year: 2012
Tongue: English
Weight: 954 KB
Volume: 72
Category: Article
ISSN: 0008-5472
DOI: 10.1158/0008-5472.can-12-0468

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## Abstract We studied the effect of polyamine depletion on growth and cell cycle characteristics of subcutaneously grown Lewis lung carcinoma (LLC) and fibrosarcoma (FIO 26) in mice. Polyamine depletion was achieved by inhibition of ornithine decarboxylase using 2‐(difluoromethyl)ornithine, limita