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Raised temperature reduces the incidence of diabetes in the NOD mouse

✍ Scribed by A. J. K. Williams; J. Krug; E. F. Lampeter; K. Mansfield; P. E. Beales; A. Signore; E. A. M. Gale; P. Pozzilli


Book ID
104757982
Publisher
Springer
Year
1990
Tongue
English
Weight
302 KB
Volume
33
Category
Article
ISSN
0012-186X

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The development of diabetes in non-obese diabetic (NOD) mice, which normally takes between 3 and 7 months, can be accelerated by cyclophosphamide (CY) injections, with rapid progression to diabetes within only 2Β±3 weeks. This insulin-dependent diabetes mellitus (IDDM) can be prevented or delayed in