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Raf kinase inhibitor protein suppresses nuclear factor-κB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression

✍ Scribed by Anwar B. Beshir; Gang Ren; Anniefer N. Magpusao; Lauren M. Barone; Kam C. Yeung; Gabriel Fenteany

Book ID
116335529
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
768 KB
Volume
299
Category
Article
ISSN
0304-3835

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Matrix metalloproteinase (MMP) plays an important role in the invasion and metastasis of cancer cells. The inhibitory effects of bergamottin, a cytochrome P450 inhibitor from Citrus paradis (grapefruit), on tumor invasion and migration and the possible mechanisms involved in this inhibition were inv