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Radiotoxicity of an125I-Labeled DNA Intercalator in Mammalian Cells

✍ Scribed by Amin I. Kassis, Fahed Fayad, Berma M. Kinsey, Kandula S. R. Sastry and S. James Adelstein

Book ID
118749304
Publisher
Bioone
Year
1989
Tongue
English
Weight
756 KB
Volume
118
Category
Article
ISSN
0033-7587

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The radiotoxic effects of L-[methyl-11C] methionine were estimated by measuring the accumulation of DNA strand breaks. CHO, Chinese-hamster cells, were incubated in 11C-methionine-containing medium for 60 min at 37 degrees C. The number of unrepaired DNA strand breaks was then examined by the DNA-un