Radiosynthesis of methyl and heptyl [11C]Isocyanates from [11C]phosgene, application to the synthesis of carbamates: [11C]physostygmine and [11C]heptylphysostigmine
✍ Scribed by C. Crouzel; F. Hinnen; E. Maitre
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 309 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0969-8043
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We synthesized [ 11 C]methyl azide ([ 11 C]MeA) by reacting [ 11 C]methyl iodide ([ 11 C]MeI) in situ with an azide-donor and used it in the synthesis of 11 C-labeled 1,2,3-triazoles. A one-pot click approach comprised the infusion of gaseous [ 11 C]MeI into a mixture of NaN 3 , ethynylbenzene, and
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