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Preparation of [11C]methyl nona-fluorobutyl-1-sulfonate ([11C]MeONf) and its use in the synthesis of [11C]-6-OH-BTA-1

✍ Scribed by Dean Jolly; Younes Lakhrissi; Miriam M. Kovacevic; Howard Chertkow; Ralf Schirrmacher

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
110 KB
Volume
50
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The rapid, simple and high‐yield synthesis of the extraordinarily reactive ^11^C‐methylating agent, [^11^C]methyl nona‐fluorobutyl‐1‐sulfonate ([^11^C]MeONf), and its use in the synthesis of the promising β‐amyloid imaging agent, [^11^C]‐6‐OH‐BTA‐1, is reported. In terms of radioactive methylation yields, [^11^C]MeONf seems to surpass [^11^C]methyl trifluoromethansulfonate ([^11^C]MeOTf) as a methylating agent in this particular case giving the ^11^C‐labelled compound in high‐preparative radiochemical yields between 27 and 29% EOS with a minimum formation of radioactive by‐products. Copyright © 2007 John Wiley & Sons, Ltd.

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