Radiosynthesis of bromine-76 and iodine-123 labelled enantiomers of A-69024: radioligands for dopamine D1 receptor studies using PET and SPECT

Radiosynthesis of (±)-1-(2-bromo-4,5-dim

Radiosynthesis of (±)-1-(2-bromo-4,5-dimethoxybenzyl)-7-hydroxy-6-methoxy-2-[11C]-methyI-l,2,3,4-tetrahydro-isoquinoline, [11C]A-69024: A non-benzazepine antagonist for studying dopamine D1 receptors In vivo using PET

✍ Michael Kassiou; William B. Mathews; John L. Musachio; Hayden T. Ravert; Richard 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 357 KB 👁 1 views

## Abstract (±)‐1‐(2‐bromo‐4,5‐dimethoxybenzyl)‐7‐hydroxy‐6‐methoxy‐2‐[^11^C]‐methyl‐1,2,3,4‐tetrahydroisoquinoline, (HCJA‐69024, a selective ligand for the D1 receptor was prepared by __N__‐alkylation of (±)__N__‐desmethyl A‐69024 with [^11^C]methyl iodide in DMF. The radiotracer was purified by s