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Radiosynthesis and radiopharmacological evaluation of [N-methyl-11C]Org 34850 as a glucocorticoid receptor (GR)-binding radiotracer

✍ Scribed by Frank Wuest; Torsten Kniess; Brian Henry; Bernardus W.M.M. Peeters; Peter H.G. Wiegerinck; Jens Pietzsch; Ralf Bergmann


Book ID
103817190
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
331 KB
Volume
67
Category
Article
ISSN
0969-8043

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## Abstract 2‐(4‐Methoxyphenyl)‐__N__‐(4‐methylbenzyl)‐__N__‐(1‐methylpiperidin‐4‐yl)acetamide (AC90179, **4**), a highly potent and selective competitive 5‐HT~2A~ antagonist, was labeled by [^11^C]‐methylation of the corresponding desmethyl analogue **5** with [^11^C]methyl triflate. The precursor