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Radiosynthesis and PET imaging of [N-methyl-11C]LY257327 as a tracer for 5-HT transporters

✍ Scribed by Yolanda Zea-Ponce; Ronald M. Baldwin; Morgan D. Stratton; Mohammed Al-Tikriti; Robert Soufer; John M. Schaus; Robert B. Innis


Book ID
117688157
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
451 KB
Volume
24
Category
Article
ISSN
0969-8051

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## Abstract Two positron‐emitting analogues of tyrosine, __O__‐[^11^C]methyl‐L‐tyrosine and __O__‐[^18^F]fluoromethyl‐L‐tyrosine were prepared as new tumor imaging agents. The alkylating agent, [^11^C]methyl triflate or [^18^F]fluoromethyl triflate, was simply bubbled through a dimethylsulfoxide so