Radiosynthesis of O-[11C]methyl-L-tyrosine and O-[18F]Fluoromethyl-L-tyrosine as potential PET tracers for imaging amino acid transport
✍ Scribed by Ren Iwata; Shozo Furumoto; Claudio Pascali; Anna Bogni; Kiichi Ishiwata
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- French
- Weight
- 140 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-2135
- DOI
- 10.1002/jlcr.696
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✦ Synopsis
Abstract
Two positron‐emitting analogues of tyrosine, O‐[^11^C]methyl‐L‐tyrosine and O‐[^18^F]fluoromethyl‐L‐tyrosine were prepared as new tumor imaging agents. The alkylating agent, [^11^C]methyl triflate or [^18^F]fluoromethyl triflate, was simply bubbled through a dimethylsulfoxide solution of L‐tyrosine disodium salt at room temperature. After subsequent HPLC purification the labeled L‐tyrosine analogues were obtained in decay‐corrected radiochemical yields of over 50%, based on their corresponding labeling agent, with radiochemical purities always higher than 98%. The quite straightforward preparation, together with the high radiochemical yields achieved, make both these syntheses suitable for routine production. Copyright © 2003 John Wiley & Sons, Ltd.