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Radiosynthesis and biological evaluation of carbon-11-labeled N-((S)-1-((S)-1-methylpiperidin-2-yl)ethyl)acetamide derivatives as a potential radioligands for glycine transporter 1

✍ Scribed by Jun Toyohara; Kichi Ishiwata; Muneyuki Sakata; Jin Wu; Kenji Hashimoto


Book ID
119331346
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
109 KB
Volume
52
Category
Article
ISSN
1053-8119

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The novel 2-mercaptoimidazole derivatives, 1-[4-((2-methoxyphenyl)-1-piperazinyl)butyl]-2-mercaptoimidazole (3) and methyl[4-((2-methoxyphenyl)-1-piperazinyl))butyl] (2-mercapto-1-methylimidazol-5-yl)methanamide ( 8), were efficiently labelled with 11 C through methylation of the thioketone function