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Radiolabelling of pharmaceutical dosage forms by neutron activation of samarium-152

✍ Scribed by M B Awang; J G Hardy; S S Davis; I R Wilding; S J Parry

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
303 KB
Volume
33
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Samarium‐152 can be activated in a neutron flux for the labelling of pharmaceutical dosage forms for evaluation by gamma scintigraphy. The samarium is incorporated as samarium oxide powder which is available with ^152^Sm in its natural isotopic abundance or isotopically enriched. The yield of ^153^Sm was reduced considerably following the neutron activation of the non‐isotopically enriched oxide. This can be attributed to the high neutron capture by ^149^Sm present in the non‐isotopically enriched oxide. In order to keep the mass of the added oxide powder to the minimum and also to reduce the neutron irradiation time, it is recommended that samarium oxide enriched with ^152^Sm should be used routinely when radiolabelling pharmaceutical dosage forms.

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