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Radiolabeling of ginkgolide B with 18F

✍ Scribed by Makiko Suehiro; Norman R. Simpson; Ronald van Heertum

Book ID
102374161
Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
108 KB
Volume
47
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Ginkgolide B, a terpene trilactone constituent of Gingko biloba extracts and an antagonist for the platelet activating factor (PAF) receptor, was radiolabeled with the positron emitter ^18^F for visualizing its in vivo behavior using positron emission tomography (PET). The 7‐[^18^F]fluoro analog of ginkgolide B (7‐^18^FGB) was synthesized via nucleophilic displacement of the triflate group at C7 with [^18^F]fluoride. The reaction was complete in 5–10 min, affording 7‐^18^FGB in an average radiochemical yield of approximately 16% (decay corrected). The average specific activity at E.O.S. was approximately 40 GBq/Β΅mol, and the radiochemical and chemical purity was greater than 95%. Copyright Β© 2004 John Wiley & Sons, Ltd.

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