Radioimmunotherapy With Astatine-211 Using Chimeric Monoclonal Antibody U36 in Head and Neck Squamous Cell Carcinoma
✍ Scribed by Cheng, Junping; Ekberg, Tomas; Engström, Mats; Nestor, Marika; Jensen, Holger J.; Tolmachev, Vladimir; Anniko, Matti
- Book ID
- 125457855
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 287 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0023-852X
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## Abstract ## Background Despite improvements in locoregional treatment of stages III/IV squamous cell carcinoma of the head and neck (HNSCC), local and distant failure rates remain high. An effective adjuvant therapy is required for these patients. Among novel approaches is radioimmunotherapy, i
Nude mice carrying human squamous-cell carcinoma xenografts were given i.v. injections of radiolabelled monoclonal antibodies (Mas). MAb E 48, which reacts with squamouscell carcinomas, was labelled with i3'l, while a second control MAb of similar immunoglobulin subclass was labelled with lZ5l. Both
## Background: There is a need for a classification system for prognosis based on the tnm system for patients with squamous cell carcinoma of the head and neck such that patient groupings are homogeneous within and heterogeneous between. ## Methods: Six hundred fifty-five consecutive patients wit