Using a double antibody radioimmunoassay test, a-fetoprotein was elevated (i.e., over 40 ng/ml) in 72% of patients with hepatocellular carcinoma, 75% of patients with teratocarcinoma or embryonal cell carcinoma of the testis, 23% of patients with pancreatic carcinoma, 18% of patients with gastric ca
Radioimmunoassay of alpha-fetoprotein: A contribution to the diagnosis of choriocarcinoma and hydatidiform mole
✍ Scribed by M. Seppälä; K. D. Bagshawe; E. Ruoslahti
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- French
- Weight
- 215 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Determination of the circulating alpha fetoprotein (AFP) can be used to differentiate between choriocarcinoma or hydatidiform mole and normal pregnancy. Whilst a positive pregnancy test is common to all these states, the serum AFP was found to be elevated only when a fetus was present.
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Partial hydatidiform moles (PM) are rare. They occur in 1:10,000 to 1:100,000 pregnancies.li2 The pre-evacuation clinical diagnosis of PM in more than 90% of patients is either missed or incomplete abortion, the diagnosis being made only af- ter histologic review of curettage specimen^.^
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