✦ LIBER ✦

Radioimmune assay for the diagnosis of human cancer

✍ Scribed by Marianne L. Egan; John E. Coligan; Charles W. Todd

Publisher: John Wiley and Sons
Year: 1974
Tongue: English
Weight: 462 KB
Volume: 34
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(197410)34:8+<1504::aid-cncr2820340823>3.0.co;2-q

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✦ Synopsis

Radioimmune assay techniques based on tumor-associated antigens are finding application in the diagnosis of human cancer. There are two basic forms of radioimmune assay. One is based on complete saturation of the antibodies with antigen, and the other is based on a progressive filling of the antibody binding sites. The specificity and sensitivity of any assay depend primarily on the antiserum used. For high sensitivity a high binding constant for the antibody is important. The preparation of a suitable antiserum is described. Specificity in a radioimmune assay is never absolute, but may be improved through knowledge of the structure of the antigen. These principles are illustrated with the carcinoembryonic antigen.

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