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Comparison of radioligand assay and immunostaining for epidermal growth factor receptor in human breast cancer

✍ Scribed by D. J. Hastrich; J. M. Dunn; S. Nicholson; P. Newcomb; Professor J. R. Farndon

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
394 KB
Volume
81
Category
Article
ISSN
0007-1323

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✦ Synopsis

Abstract

Epidermal growth factor (EGF) receptor status is a useful prognostic indicator in women with breast cancer. Lack of standardization and correlation of methodology for the detection of EGF receptor has hampered its further evaluation. EGF receptor status was ascertained by immunohistochemistry and radioligand assay in 120 breast cancers. Of 52 tumours negative for EGF receptor on radioligand assay, 47 were negative on immunohistochemistry and, of 68 tumours positive for the receptor on assay, 52 were positive on immunohistochemistry. If the more widely evaluated radioligand assay is assumed to be the β€˜gold standard’, immunohistochemistry has a sensitivity of 81 per cent and a specificity of 91 per cent.

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