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Plasma levels of vascular endothelial growth factor (VEGF) and its receptor, flt-1, in haematological cancers: A comparison with breast cancer

✍ Scribed by Funmi M. Belgore; Gregory Y. H. Lip; David Bareford; Martin Wadley; Paul Stonelake; Andrew D. Blann

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 29 KB
Volume: 66
Category: Article
ISSN: 0361-8609
DOI: 10.1002/1096-8652(200101)66:1<59::aid-ajh1011>3.0.co;2-z

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✦ Synopsis

Raised plasma VEGF is found in some cancers but levels of its receptor soluble Flt-1 (sFlt-1) are unreported. Hypothesising increased levels to be present in haematological cancers, we measured both by ELISA in 22 patients with haematological cancer, 22 with breast cancer, and in age-and sex-matched controls. VEGF was raised in both patients groups compared to controls (P < 0.01) but was higher in haematological cancer compared to breast cancer (P = 0.0238). There was no difference in levels of sFlt-1. Our data point to changes in levels of plasma VEGF, but not sFlt-1, in haematological cancer that may have pathophysiological consequences.

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