𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Radiobromine labeled cholesterol analogs. Synthesis and tissue distribution of bromine-82 labeled 6-bromocholesterol

✍ Scribed by Liu Bo-Li; Jin Yu-Tai; Pan Zhong-Yun; Minoru Maeda; Masaharu Kojima

Book ID
102368903
Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
271 KB
Volume
19
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Bromine‐82 labeled 6‐bromocholesterol (CL‐6‐Br‐82) was prepared by the reaction of 6‐chloromercurycholesterol with bromine‐82 labeled bromine in chloroform. Tissue distribution of CL‐6‐Br‐82 in rats was determined. The adrenal uptake of CL‐6‐Br‐82 reached a maximum of 136 %dose/g at 5 days after injection. The adrenal‐to‐liver ratio increased from 57 at 3 days to 141 at 5 days. The substitution of radiobromine for radioiodine in 6‐iodo‐cholesterol (CL‐6‐I) resulted in an agent which demonstrates less affinity for the adrenal gland than CL‐6‐I itself.

📜 SIMILAR VOLUMES

125I-Labeled 2-O- and 3-O-m-iodobenzyl,
125I-Labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid: synthesis and preliminary tissue distribution
✍ Fumihiko Yamamoto; Eri Kuwano; Tetsuo Kaneshiro; Shigeki Sasaki; Minoru Maeda 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 157 KB

## Abstract Three ^125^I‐labeled 2__‐O‐__ and 3__‐O‐m‐__iodobenzyl, and 6__‐O‐m‐__iodophenyl derivatives of L‐ascorbic acid were prepared by melt exchange procedures in isolated radiochemical yields of 12–60% after HPLC purification. Biodistribution studies in tumor‐bearing mice showed very differe