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125I-Labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid: synthesis and preliminary tissue distribution

✍ Scribed by Fumihiko Yamamoto; Eri Kuwano; Tetsuo Kaneshiro; Shigeki Sasaki; Minoru Maeda

Publisher: John Wiley and Sons
Year: 2003
Tongue: French
Weight: 157 KB
Volume: 46
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.714

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✦ Synopsis

Abstract

Three ^125^I‐labeled 2__‐O‐__ and 3__‐O‐m‐iodobenzyl, and 6‐O‐m‐__iodophenyl derivatives of L‐ascorbic acid were prepared by melt exchange procedures in isolated radiochemical yields of 12–60% after HPLC purification. Biodistribution studies in tumor‐bearing mice showed very different in vivo tissue uptake properties from previous results obtained with ^14^C‐labeled ascorbic acid and 6‐deoxy‐6‐[^18^F]fluoro‐L‐ascorbic acid. None of these seems to be suitable radioiodinated analogs of L‐ascorbic acid for imaging study of its in vivo biochemistry. Copyright © 2003 John Wiley & Sons, Ltd.

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