## Abstract Tritium labelled (17‐^3^H) 16α, 17α‐epoxy‐androst‐4‐en‐3‐one and 16α, 17α‐epoxy‐estra‐1,3,5(10)‐trien‐3‐ol have been prepared on a large scale (200‐300 mg amounts) with efficient (i.e. activity of product exactly predictable) introduction of label. The preparative method is very inexpen
Radioactive labeling of α-bungarotoxin with tritium
✍ Scribed by Vesna A. Eterović; Ray G. Aune; Edward L. Bennett
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- English
- Weight
- 549 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0003-2697
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o-Bungarotoxin has been labeled with [3H]pyridoxamine phosphate, by reaction with pyridoxal phosphate followed by reduction with sodium boro["H]hydride. Specific activities of up to 27 Ci/mmol have been obtained. Mono-and dilabeled toxins bind irreversibly to the acetylcholine receptor from Torpedo
## Abstract Various approaches to the synthesis of tritium‐labelled BIIL 260 with high specific radioactivity were investigated. Attempts to incorporate tritium directly into BIIL 260 were made by solid‐phase isotope exchange with tritium gas and by isotope exchange with tritiated water which yield