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Radical Cyclization Approach to Cyclonucleosides

โœ Scribed by Maria Luisa Navacchia; Antonio Manetto; Pier Carlo Montevecchi; Chryssostomos Chatgilialoglu


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
166 KB
Volume
2005
Category
Article
ISSN
1434-193X

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## Abstract For Abstract see ChemInform Abstract in Full Text.

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A Diastereoselective Radical Cyclization Approach to Pyroglutamates. -The 5-endo radical cyclization of pyruvic acid derived dehydroalanines (VI) possessing chiral ester auxiliaries is reported. The diastereoselectivity can be increased up to 6:1 by cyclization of the corresponding 8-phenylmenthyl