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Radical cyclisation of amino aldehydes leading to hydroxy pyrrolidines and piperidines

โœ Scribed by Andrew F. Parsons; Robert M. Pettifer


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
201 KB
Volume
38
Category
Article
ISSN
0040-4039

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Tributyltin hydride-mediated radical cyc
โœ David Bebbington; Jon Bentley; Paul A Nilsson; Andrew F Parsons ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 83 KB

The tributyltin hydride-mediated cyclisation of unsaturated ethers bearing an aldehyde or a,b-unsaturated ketone group is reported. Cyclisation proceeds via addition of the tributyltin radical to the carbonyl double bond and the resultant O-stannyl ketyl can add intramolecularly to electron-rich dou