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Intramolecular cyclization of ω-primary amino electrophilic olefins to functionalized pyrrolidines and piperidines.

✍ Scribed by N. Knouzi; M. Vaultier; L. Toupet; R. Carrie


Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
241 KB
Volume
28
Category
Article
ISSN
0040-4039

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Cyciiition of r,b-alkenylimines with bromine in dichloromethane gave instantaneous formation of cyclic iminium bromides, which were converted into either pyrrolidines or piperidines, depending upon the substitution pattern. This reaction has been applied in the synthesis of 2.azaspiro compounds.